Fri Aug 12 2022

93 articles - From Friday Aug 05 2022 to Friday Aug 12 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19 : A Randomized Controlled Trial.

Compared with placebo, ensovibep did not improve clinical outcomes for hospitalized participants with COVID-19 receiving standard care, including remdesivir; no safety concerns were identified. Primary funding source National Institutes of Health.

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How Would You Treat This Patient With Pulmonary Embolism? : Grand Rounds Discussion From Beth Israel Deaconess Medical Center.

Here, a hematologist and a cardiology and vascular medicine specialist discuss these guidelines in the context of the care of a patient with pulmonary embolism. They discuss advanced therapies such as catheter-directed thrombolysis in the short-term management of patients with intermediate-risk disease, recurrence risk stratification at presentation, and ideal antithrombotic regimens for patients whose pulmonary embolism was associated with a transient minor risk factor.

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Reinfection and Risk Behaviors After Treatment of Hepatitis C Virus Infection in Persons Receiving Opioid Agonist Therapy : A Cohort Study.

Reinfection with HCV was low but was highest in the first 24 weeks after treatment completion and among people with ongoing injecting drug use and needle-syringe sharing. Primary funding source Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc.

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Lancet

Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain: a prospective observational cohort study.

Lesion swabs showed the highest viral loads, which, combined with the history of sexual exposure and the distribution of lesions, suggests close contact is probably the dominant transmission route in the current outbreak. None.

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Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study.

Further research that distinguishes potential mechanisms driving post-COVID-19-related symptomatology is required. Funding ZonMw; Dutch Ministry of Health, Welfare, and Sport; Dutch Ministry of Economic Affairs; University Medical Center Groningen, University of Groningen; Provinces of Drenthe, Friesland, and Groningen.

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Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3-07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study.

The international scale of the study supports the generalisability of the results. Funding National Health and Medical Research Council of Australia, Susan G Komen for the Cure, Breast Cancer Now, OncoSuisse, Dutch Cancer Society, Canadian Cancer Trials Group.

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N Engl J Med

Germline Mutations in CIDEB and Protection against Liver Disease.

We found that rare coding variants in conferred substantial protection from liver disease. (Funded by Regeneron Pharmaceuticals.).

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Low-Dose Subcutaneous or Intravenous Monoclonal Antibody to Prevent Malaria.

In this small trial, L9LS administered intravenously or subcutaneously protected recipients against malaria after controlled infection, without evident safety concerns. (Funded by the National Institute of Allergy and Infectious Diseases; VRC 614 ClinicalTrials.gov number, NCT05019729.).

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Removal of Small, Asymptomatic Kidney Stones and Incidence of Relapse.

The removal of small, asymptomatic kidney stones during surgery to remove ureteral or contralateral kidney stones resulted in a lower incidence of relapse than nonremoval and in a similar number of emergency department visits related to the surgery. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and the Veterans Affairs Puget Sound Health Care System; ClinicalTrials.gov number, NCT02210650.).

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Supplemental Vitamin D and Incident Fractures in Midlife and Older Adults.

(Funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases; VITAL ClinicalTrials. gov number, NCT01704859.).

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Trial of Anti-BDCA2 Antibody Litifilimab for Cutaneous Lupus Erythematosus.

In a phase 2 trial involving participants with cutaneous lupus erythematosus, treatment with litifilimab was superior to placebo with regard to a measure of skin disease activity over a period of 16 weeks. Larger and longer trials are needed to determine the effect and safety of litifilimab for the treatment of cutaneous lupus erythematosus. (Funded by Biogen; LILAC ClinicalTrials.gov number, NCT02847598.).

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Trial of Cinpanemab in Early Parkinson's Disease.

In participants with early Parkinson's disease, the effects of cinpanemab on clinical measures of disease progression and changes in DaT-SPECT imaging did not differ from those of placebo over a 52-week period. (Funded by Biogen; SPARK ClinicalTrials.gov number, NCT03318523.).

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Trial of Prasinezumab in Early-Stage Parkinson's Disease.

Prasinezumab therapy had no meaningful effect on global or imaging measures of Parkinson's disease progression as compared with placebo and was associated with infusion reactions. (Funded by F. Hoffmann-La Roche and Prothena Biosciences; PASADENA ClinicalTrials.gov number, NCT03100149.).

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Ann Intern Med

Eating Disorders.

Persons with eating disorders frequently present to primary care providers, who may also be responsible for their general medical management. This article reviews the diagnosis, medical assessment, and treatment of the most common eating disorders.

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Unintended Consequences of SCOTUS Abortion Decision for Patients With Rheumatic Diseases.

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Lancet

2022 heatwaves: a failure to proactively manage the risks.

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Depression in young people.

Emerging school-based and community-based social interventions show some promise. Depression is highly heterogeneous; therefore, a stepwise treatment approach is recommended, starting with brief psychosocial interventions, then a specific psychological therapy, and then an antidepressant medication.

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Global pandemic perspectives: public health, mental health, and lessons for the future.

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N Engl J Med

Audio Interview: Combating Covid-19 Today and Tomorrow.

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Audio Interview: Reinventing the Research Infrastructure to Address Covid-19.

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Audio Interview: Updated Covid-19 Vaccines and a Look at Monkeypox.

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Bronchiectasis - A Clinical Review.

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Fundamentals of Health Law - A New Perspective Series.

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Monoclonal Antibodies - A Different Approach to Combat Malaria.

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Monoclonal Antibodies for Malaria.

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Monoclonal Antibody Therapy in Parkinson's Disease - The End?

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Preemptive Removal of Small, Asymptomatic Kidney Stones.

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Spina Bifida.

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T-Cell Engagers - Modern Immune-Based Therapies for Multiple Myeloma.

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Tobacco Addiction.

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VITAL Findings - A Decisive Verdict on Vitamin D Supplementation.

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Letters&Replies

Letters to the editors and authors’ replies

Lancet

COVID-19 and microbiome diversity in sub-Saharan Africa - Author's reply.

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COVID-19 and microbiome diversity in sub-Saharan Africa.

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Funding to treat malnutrition: a need for greater transparency.

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Troubling assumptions behind GBD 2019 on the health risks of red meat.

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N Engl J Med

A Zoonotic Henipavirus in Febrile Patients in China.

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Childhood Risk Factors and Adult Cardiovascular Events.

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Childhood Risk Factors and Adult Cardiovascular Events.

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Childhood Risk Factors and Adult Cardiovascular Events.

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Childhood Risk Factors and Adult Cardiovascular Events. Reply.

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CT or Invasive Coronary Angiography in Stable Chest Pain.

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CT or Invasive Coronary Angiography in Stable Chest Pain.

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CT or Invasive Coronary Angiography in Stable Chest Pain.

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CT or Invasive Coronary Angiography in Stable Chest Pain.

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CT or Invasive Coronary Angiography in Stable Chest Pain. Reply.

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Gliflozins in the Management of Cardiovascular Disease.

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Gliflozins in the Management of Cardiovascular Disease.

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HIV Prevention and the 340B Drug Pricing Program.

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HIV Prevention and the 340B Drug Pricing Program. Reply.

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Looking Back.

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Looking Back. Reply.

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Nasal High-Flow Therapy during Neonatal Endotracheal Intubation.

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Nasal High-Flow Therapy during Neonatal Endotracheal Intubation. Reply.

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Neoadjuvant Nivolumab plus Chemotherapy in Lung Cancer.

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Neoadjuvant Nivolumab plus Chemotherapy in Lung Cancer.

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Neoadjuvant Nivolumab plus Chemotherapy in Lung Cancer. Reply.

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Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer.

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Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer. Reply.

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Nonspecific Low Back Pain.

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Nonspecific Low Back Pain.

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Nonspecific Low Back Pain. Reply.

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Oncogene Up-Regulation after Hypomethylating Therapy.

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Oncogene Up-Regulation after Hypomethylating Therapy. Reply.

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Single-Dose Amphotericin B for Cryptococcal Meningitis.

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Single-Dose Amphotericin B for Cryptococcal Meningitis. Reply.

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Understanding REM Sleep Behavior Disorder in Parkinson's Disease.

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Use of eGFR in Older Adults with Kidney Disease.

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Use of eGFR in Older Adults with Kidney Disease. Reply.

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Others

all remaining publications eg case reports, images of the month, etc…

Ann Intern Med

Annals Graphic Medicine - Dive.

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Lancet

Breast radiotherapy for ductal carcinoma in situ: could less be more?

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Epidemiological approach to ending tuberculosis in high-burden countries.

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Health at stake in Kenya elections.

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Immune tolerance induction through haematopoietic chimerism after kidney donation.

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Long COVID: which symptoms can be attributed to SARS-CoV-2 infection?

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Monkeypox as a PHEIC: implications for global health governance.

Pubmed   Journal   ReadQx   PMC

Research focus: the NHS Race & Health Observatory.

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Rights groups warn over new Tunisian constitution.

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Sexual behaviours and clinical course of human monkeypox in Spain.

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Tulio de Oliveira: collaborating to boost science in Africa.

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N Engl J Med

Bringing Sickle-Cell Treatments to Children in Sub-Saharan Africa.

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Case 23-2022: A 49-Year-Old Man with Hypoglycemia.

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Considering Race and Ethnicity in Covid Risk Assessments - Legal Concerns and Possible Solutions.

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Curtain Sign.

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Diagnostic Aspirations.

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Hair Repigmentation Induced by Nilotinib.

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Japanese Spotted Fever.

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Lupus Pernio in Sarcoidosis.

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More Than a Little Unsteady.

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Noncompete Agreements - The Need for a Refresh.

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Screening for Atrial Fibrillation in Asymptomatic Older Adults.

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Tecovirimat and the Treatment of Monkeypox - Past, Present, and Future Considerations.

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The History of Health Law in the United States.

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Understanding Covid Vaccine Efficacy over Time - Bridging a Gap Between Public Health and Health Care.

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